Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 8, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

Exploring dopaminergic activity in ring chromosome 20 syndrome: a SPECT study.

A Del Sole1, V Chiesa, G Lucignani

  • 1Department of Biomedical Sciences and Technologies and Center of Molecular and Cellular Imaging (IMAGO), University of Milan, Milan, Italy. angelo.delsole@unimi.it

The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR), [And] Section of the Society Of
|October 8, 2010
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biochemical fingerprinting of dried blood serum from chronic lymphocytic leukemia patients by Raman spectroscopy: Towards prognostic classification.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2025
Same author

UBA5-epileptic encephalopathy: new patient, a novel variant, and a review of epileptic phenotypes.

Epileptic disorders : international epilepsy journal with videotape·2025
Same author

Determinants of sustainable adoption in primary care of a clinical decision support system for antimicrobial prescribing: A qualitative study.

Infectious diseases now·2025
Same author

Retrospective multicenter study on cryptogenic NORSE/FIRES patients treated with anakinra.

Seizure·2025
Same author

Assessment of Clinical and Neurological Alterations Before Radiation Therapy in Children With Malignant Brain Tumours.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

Comparison of "IN-REC-SUR-E" and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN-REC-LISA trial).

Trials·2024

This study found that higher seizure frequency in ring chromosome 20 epilepsy correlates with increased dopamine D2 receptor density and decreased dopamine transporter (DAT) expression. These findings suggest dopaminergic system involvement in r(20) epilepsy.

Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Dopaminergic system dysfunction is implicated in seizure propagation.
  • Impaired DOPA metabolism observed in ring chromosome 20 [r(20)] epilepsy patients via PET studies.
  • Previous research suggests a potential role for dopamine in epilepsy.

Purpose of the Study:

  • To investigate correlations between r(20) mosaicism, clinical variables, and dopamine transporter (DAT) expression.
  • To assess the relationship between r(20) mosaicism, clinical variables, and post-synaptic D2 receptor density.
  • To explore the dopaminergic system's role in r(20) epilepsy.

Main Methods:

  • SPECT imaging used to measure DAT expression with [¹²³I]ioflupane.
  • SPECT imaging used to measure D2 receptor density with [¹²³I]IBZM.

More Related Videos

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
07:25

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Published on: March 27, 2018

Related Experiment Videos

Last Updated: Jun 8, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
07:25

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

Published on: March 27, 2018

  • Linear correlation analyses performed between r(20) mosaicism, clinical data, and radioligand binding.

    • Main Results:

    • Significant positive correlation found between seizure frequency and r(20) mosaicism (r=0.903, P<0.05).
    • Negative correlation observed between r(20) mosaicism and [¹²³I]ioflupane binding in the putamen and caudate nucleus (r=-0.692, r=-0.807; P<0.05).
    • Positive correlation detected between seizure frequency and post-synaptic D2 receptor density (r=0.925, P<0.05).

    Conclusions:

    • Striatal neurons are implicated in the pathophysiology of r(20) epilepsy.
    • The observed relationship between r(20) mosaicism and DAT expression suggests potential therapeutic targets.
    • Pharmacological interventions targeting the dopaminergic system may benefit patients with this rare epilepsy form.