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Relationship of white blood cell counts, haemoglobin and ESR with IHD
Farhana Shahzad1, Shahzad Tawwab, Afia Abbas
1Department of Immunology, University of Health Sciences, Lahore, Pakistan. shahzadtawwab@hotmail.com
Insights
White blood cell counts, lower hemoglobin, and higher ESR are associated with ischemic heart disease (IHD) in non-diabetic men. These routinely measured parameters may help predict IHD risk.
Area of Science:
- Cardiology
- Hematology
- Public Health
Background:
- Ischemic heart disease (IHD) poses a significant global health burden.
- Identifying accessible biomarkers for IHD risk stratification is crucial for early intervention.
Purpose of the Study:
- To investigate the association between complete blood cell counts, hemoglobin, and erythrocyte sedimentation rate (ESR) with IHD.
- To evaluate these hematological parameters as potential predictors in a high-risk, non-diabetic native population.
Main Methods:
- A case-control study involving 93 male IHD patients and 96 matched controls (40-60 years old).
- Comparison of total leukocyte count, neutrophil and lymphocyte levels, hemoglobin, and ESR between IHD patients and controls.
- All participants were confirmed non-diabetics.
Main Results:
- Significantly elevated total leukocyte and neutrophil counts in IHD patients compared to controls (p < 0.001).
- Significantly lower lymphocyte counts in the IHD group (p < 0.001).
- Lower hemoglobin levels (p < 0.001) and higher ESR (p = 0.030) were observed in patients with IHD.
Conclusions:
- Findings suggest a correlation between specific hematological markers and IHD in the studied population.
- These routinely measured parameters (leukocytes, hemoglobin, ESR) may serve as valuable, cost-effective indicators for predicting IHD risk.
- Further research is warranted to confirm the prognostic value of these variables for future and secondary ischemic events.
Objectives:
To find any association of white blood cells, haemoglobin and ESR with ischemic heart disease in high risk native population.
Methodology:
The study included 93 male patients with Ischemic heart disease, between 40 and 60 years of age; 96 age and gender matched subjects. All study participants were non-diabetics. Complete blood cells count, haemoglobin and ESR levels were compared between the patient and control groups.
Results:
Total leukocyte counts along with neutrophils were significantly higher in the test group compared to the control population (p < 0.001) and lymphocytes were significantly lower (p < 0.001) in the patient group as compared to the control group. Haemoglobin levels were significantly lower (p < 0.001) and ESR was higher (p = 0.030) in the patient group as compared to the control group.
Conclusion:
Although, our findings of the study variables extend previous reports, the prevalence and prognostic importance of theses variables in IHD should be assessed in future experimental studies. These parameters could be important in public health because they are routinely measured by clinicians and may be helpful to predict the risk of future and secondary ischemic events in a high risk population.
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