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Effect of glycaemic status on left ventricular diastolic function in normotensive type 2 diabetic patients

Hameedullah1, Muhammad Faheem, Sher Bahadar

  • 1Department of Cardiology, Lady Reading Hospital, Peshawar, Pakistan. hameedullah@yahoo.com

Journal of Ayub Medical College, Abbottabad : JAMC
|October 9, 2010
PubMed

Insights

Poorly controlled type 2 diabetes significantly increases the risk of left ventricular diastolic dysfunction. Echocardiography reveals that worsening glycemic control correlates with the severity of this diabetic cardiomyopathy.

Area of Science:

  • Cardiology
  • Diabetology
  • Medical Imaging

Background:

  • Diabetes mellitus is a known risk factor for cardiac dysfunction, specifically diabetic cardiomyopathy, affecting both diastolic and systolic functions of the left ventricle.
  • Echocardiography is a key diagnostic tool for identifying diastolic dysfunction, and screening for asymptomatic diabetic cardiomyopathy is recommended in diabetic patients.
  • Early detection and management of diabetic cardiomyopathy are crucial to prevent disease progression.

Purpose of the Study:

  • To investigate the impact of glycemic status on left ventricular diastolic function in patients with type 2 diabetes.
  • To assess the prevalence and severity of diastolic dysfunction in relation to glycemic control.

Main Methods:

  • A descriptive case series involving 60 normotensive type 2 diabetic patients.
  • Patients were categorized into three groups based on glycemic control: well-controlled, moderately controlled, and poorly controlled.
  • Left ventricular diastolic function was evaluated using echocardiography, measuring parameters such as E/A ratio, IVRT, DT, and Em.

Main Results:

  • Left ventricular diastolic dysfunction was significantly more prevalent in poorly controlled diabetic patients (80%) compared to moderately (45%) and well-controlled (25%) groups.
  • Key echocardiographic indices of diastolic function (E/A ratio, IVRT, DT, Em) showed a significant correlation with glycemic control (HbA1c levels).
  • A strong correlation was observed between HbA1c levels and diastolic indexes, indicating that poorer glycemic control is associated with more severe diastolic dysfunction.

Conclusions:

  • Diastolic dysfunction is a common complication in type 2 diabetes, particularly in patients with poor glycemic control.
  • The severity of left ventricular diastolic dysfunction is directly correlated with the level of glycemic control.
Abstract

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