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Acute phase reactants in patients with coronary slow flow phenomenon
Nihat Madak1, Yunus Nazlı, Haluk Mergen
1Department of Cardiology, Faculty of Medicine, University of Celal Bayar, Manisa, Turkey. nihatmadak@yahoo.com
Summary
Patients with coronary slow flow phenomenon have higher levels of high sensitivity C-reactive protein (Hs-CRP) and N-terminal pro-brain natriuretic peptide (NT proBNP). These elevated biomarkers correlate with reduced coronary flow rates, indicating their potential role in this condition.
Area of Science:
- Cardiology
- Biomarkers
- Coronary Artery Disease
Background:
- Coronary slow flow phenomenon (CSFP) is a condition affecting coronary artery blood flow.
- Identifying reliable biomarkers for CSFP is crucial for diagnosis and management.
Purpose of the Study:
- To investigate serum levels of key biomarkers, including high sensitivity C-reactive protein (Hs-CRP) and N-terminal pro-brain natriuretic peptide (NT proBNP), in patients with CSFP.
- To assess the correlation between these biomarkers and coronary flow rates.
Main Methods:
- Cross-sectional observational study involving 82 patients with CSFP and 34 controls.
- Measurement of serum Hs-CRP, NT proBNP, thyroid hormones, fibrinogen, erythrocyte sedimentation rate, and leukocyte count.
- Coronary flow assessed using Thrombolysis In Myocardial Infarction (TIMI) frame count.
Main Results:
- Significantly higher serum levels of Hs-CRP and NT proBNP were observed in patients with CSFP compared to controls.
- No significant differences in thyroid hormones, fibrinogen, sedimentation rate, or leukocyte count were found between groups.
- Positive correlations were established between TIMI frame counts and levels of both Hs-CRP and NT proBNP.
Conclusions:
- Elevated serum Hs-CRP and NT proBNP levels are characteristic of coronary slow flow phenomenon.
- These biomarkers show a positive correlation with reduced coronary flow, suggesting their utility in evaluating CSFP.
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