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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (MĂĽllerian ducts). These ducts form the basis for the male...

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Related Experiment Video

Updated: Jun 8, 2026

Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

Genetic regulation of prostate development.

Joshua J Meeks1, Edward M Schaeffer

  • 1Department of Urology, Northwestern University School of Medicine, Chicago, Illinois, USA.

Journal of Andrology
|October 9, 2010
PubMed
Summary

Androgen signaling drives prostate development and function. Understanding key molecules and pathways involved in this process is crucial for addressing age-related prostate diseases like hyperplasia and cancer.

Area of Science:

  • Urology
  • Developmental Biology
  • Molecular Endocrinology

Background:

  • Prostatic development and adult function are critically regulated by androgens and androgen receptor signaling.
  • Pathologic conditions such as hyperplastic and malignant prostate growth in aging males are linked to the absence of androgens.
  • Insights into prostate pathology can be gained from studying the signaling networks governing normal prostatic growth.

Purpose of the Study:

  • To review key molecules and signaling pathways essential for prostate development.
  • To highlight the roles of these molecules and pathways in both normal prostatic growth and associated pathologies.
  • To provide a foundation for understanding the etiology of prostate diseases.

Main Methods:

  • Review of existing scientific literature on prostatic development and signaling.

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Generation of a Mouse Prostate Organoid-Based Model for Studying Host-Pathogen Interactions

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Last Updated: Jun 8, 2026

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Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
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Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

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  • Identification and discussion of critical molecular players (e.g., Nkx3.1, sonic hedgehog, Sry box 9).
  • Analysis of key signaling pathways (e.g., fibroblast growth factor, wingless).

    • Main Results:

    • Identified Nkx3.1, sonic hedgehog, and Sry box 9 as key molecules in prostatic development.
    • Highlighted the importance of fibroblast growth factor and wingless signaling pathways.
    • Established the link between developmental pathways and prostatic pathology.

    Conclusions:

    • Key molecules and signaling pathways are fundamental to prostate development.
    • Dysregulation or altered function of these pathways may contribute to prostate diseases.
    • Further research into these mechanisms is vital for therapeutic advancements in urologic conditions.