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Updated: Jun 8, 2026

Triplet Fusion Upconversion Nanocapsule Synthesis
Published on: September 7, 2022
Carotenoids and related polyenes, part 12. First total synthesis and absolute configuration of 3'-deoxycapsanthin and
Yumiko Yamano1, Mahankhali Venu Chary, Akimori Wada
1Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University, Japan. y-yamano@kobepharma-u.ac.jp
Abstract:
The synthesis of 3'-deoxycapsanthin (1) and 3,4-didehydroxy-3'-deoxycapsanthin (2), carotenoids of paprika, has been achieved by employing Lewis acid-promoted regio- and stereoselective rearrangement of the C(15)-epoxy dienal 5a. The absolute stereochemistry of the newly formed C-5 chiral center of rearrangement product 6a was determined to be (R) from its alternative synthesis derived from (+)-(R)-camphonanic acid (11).
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