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[Sexual dysfunction induced by antidepressants].

Joachim Frost1, Pål Sandvik, Olav Spigset

  • 1Avdeling for klinisk farmakologi, St. Olavs hospital, 7006 Trondheim, Norway. joachim.frost@legemidler.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|October 9, 2010
PubMed
Summary
This summary is machine-generated.

Selective serotonin reuptake inhibitors (SSRIs) can cause sexual dysfunction in 40% of patients. Bupropion, mirtazapine, sildenafil, or tadalafil may effectively manage these antidepressant-induced sexual side effects.

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Sexual Medicine

Background:

  • Sexual dysfunction frequently co-occurs with depressive disorders.
  • Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), can induce or worsen sexual dysfunction as a significant adverse effect.
  • Approximately 40% of patients on SSRIs report sexual side effects, potentially leading to treatment noncompliance.

Purpose of the Study:

  • To review the incidence of antidepressant-induced sexual dysfunction.
  • To explore effective management strategies for sexual dysfunction in patients with depressive disorders.
  • To evaluate alternative pharmacological treatments and adjuncts.

Main Methods:

  • Literature review of studies on antidepressants and sexual dysfunction.
  • Analysis of clinical trial data regarding sexual side effect profiles.
  • Examination of evidence for bupropion, mirtazapine, sildenafil, and tadalafil in managing sexual dysfunction.

Main Results:

  • SSRIs are associated with a 40% incidence of sexual dysfunction.
  • The norepinephrine and dopamine reuptake inhibitor bupropion shows an incidence of sexual adverse effects comparable to placebo.
  • Adjunctive or alternative treatments such as bupropion, mirtazapine, sildenafil, and tadalafil have demonstrated efficacy in managing sexual dysfunction.

Conclusions:

  • Sexual dysfunction is a common and problematic adverse effect of certain antidepressants.
  • Bupropion and mirtazapine represent viable alternatives or adjuncts for managing antidepressant-induced sexual dysfunction.
  • Pharmacological interventions like sildenafil and tadalafil show promise in treating sexual dysfunction in men with depression.