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Updated: Jun 8, 2026
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Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
Published on: May 23, 2014
Endometrial stromal sarcoma
Geetha Puliyath1, V Rajasekharan Nair, Swetha Singh
1Department of Obstetrics and Gynaecology, SUT Academy of Medical Sciences, Vattappara, Trivandrum, Kerala, India.
Summary
Endometrial stromal sarcoma (ESS) is a rare uterine cancer. Early diagnosis of low-grade ESS is crucial for effective surgical treatment, even when presenting as a rapidly growing fibroid.
Area of Science:
- Gynecologic Oncology
- Pathology
- Reproductive Endocrinology
Background:
- Endometrial stromal sarcoma (ESS) is a rare malignancy of the uterine lining.
- It typically affects women aged 40-50.
- Rapid uterine enlargement can mimic benign conditions like fibroids.
Observation:
- A case of low-grade ESS presented as a rapidly enlarging fibroid uterus in a patient with secondary infertility.
- Preoperative endometrial aspiration raised suspicion of sarcomatous change.
- Histopathology confirmed low-grade ESS after total hysterectomy.
Findings:
- Preoperative diagnosis of low-grade ESS was achieved through endometrial aspiration.
- Histopathological examination confirmed the diagnosis.
- Surgical intervention was planned based on the accurate preoperative diagnosis.
Implications:
- This case highlights the importance of considering ESS in patients with rapidly enlarging fibroid uteri.
- Accurate preoperative diagnosis is vital for appropriate surgical planning and management of ESS.
- Awareness of ESS presentation is crucial for gynecologists and oncologists.
