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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

Published on: March 7, 2025

Sequential therapy for Helicobacter pylori eradication.

Mustafa Yakut¹, Kubilay Çinar, Gülseren Seven

¹Department of Gastroenterology, Ankara University, School of Medicine, Ankara. musyakut@gmail.com

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology

|October 9, 2010

Summary

Sequential therapy for Helicobacter pylori achieved 88% eradication initially, persisting in 77% after one year. This offers a viable alternative to declining triple therapy success rates.

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Area of Science:

Gastroenterology
Infectious Diseases
Microbiology

Background:

Helicobacter pylori eradication rates with standard triple therapy are declining.
Naive H. pylori-positive patients require effective treatment alternatives.

Purpose of the Study:

To compare the efficacy of sequential therapy versus ranitidine bismuth citrate-based triple therapy for H. pylori eradication.
To assess the long-term persistence of H. pylori eradication achieved with sequential therapy.

Main Methods:

Prospective study comparing sequential therapy (pantoprazole, amoxicillin, metronidazole, tetracycline) with ranitidine bismuth citrate-based triple therapy.
Invasive H. pylori tests used for diagnosis and one-month post-treatment evaluation.
One-year follow-up using H. pylori stool antigen test for sequential therapy group.

Main Results:

Initial eradication rates: 88% for sequential therapy vs. 95% for ranitidine bismuth citrate group.
One-year follow-up showed sustained eradication in 77% of patients treated with sequential therapy.
Both treatments were well-tolerated with minimal side effects.

Conclusions:

Sequential therapy demonstrates high initial H. pylori eradication rates.
Sustained eradication with sequential therapy is achieved in a significant majority of patients at one year.
Sequential therapy is a promising option for H. pylori eradication, especially given the decline in triple therapy effectiveness.