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Preparation and Reactions of Sulfides

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.

Sulfur Assimilation

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Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to become...

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Related Experiment Video

Updated: Jun 8, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

Sulfur-containing amides from Entada phaseoloides.

Hui Xiong¹, Er Xiao, Ying-Hong Zhao

¹College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, China.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica

|October 12, 2010

Summary

This summary is machine-generated.

Researchers identified four sulfur-containing amide compounds from Entada phaseoloides seeds, including a novel compound and one previously undiscovered in the Entada genus. This study enhances our understanding of the plant

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Published on: June 13, 2022

Area of Science:

Phytochemistry
Natural Product Chemistry
Organic Chemistry

Background:

Entada phaseoloides (L.) Merr. is a plant species with potential medicinal properties.
Understanding its chemical constituents is crucial for exploring its pharmacological applications.

Purpose of the Study:

To isolate and characterize the chemical constituents present in the seeds of Entada phaseoloides.
To identify novel compounds and expand the known chemical diversity of the Entada genus.

Main Methods:

Extraction of seeds using 70% ethanol at room temperature.
Purification using silica gel and reversed-phase silica gel column chromatography.
Structure elucidation via spectral analysis and semi-preparative High-Performance Liquid Chromatography (HPLC).

Main Results:

Four sulfur-containing amide compounds were successfully isolated from the n-BuOH-soluble fraction.
The identified compounds are entadamide A-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranoside (1), entadamide A (2), entadamide A-beta-D-glucopyranoside (3), and clinacoside C (4).
Compound 1 represents a new chemical entity, and compound 4 is reported from the Entada genus for the first time.

Conclusions:

The chemical investigation of Entada phaseoloides seeds yielded four unique sulfur-containing amide compounds.
The discovery of a new compound and the first isolation of clinacoside C from this genus contribute significantly to natural product chemistry.
These findings provide a basis for further research into the biological activities and potential applications of these compounds.