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Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941
Published on: April 28, 2019
Fully automated production of iodine-124 using a vertical beam
Kotaro Nagatsu1, Masami Fukada, Katsuyuki Minegishi
1Molecular Imaging Center, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage, Chiba 263-8555, Japan. nagatsu@nirs.go.jp
Abstract:
A fully automated system for the production of iodine-124, based on techniques of vertical-beam irradiation and dry distillation, was developed. The system, coupled with a capsulated target, was able to irradiate the (124)TeO(2) target up to 29 μA for 1-4h, which yielded iodine-124 with an almost constant yield of 6.9 MBq/μAh at the end of bombardment. All procedures were performed automatically and repeatedly. The newly developed system would be suitable for routine, large-scale productions of iodine-124.
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