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Updated: Jun 8, 2026

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
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Effect of titanium maxillofacial implants and osteosynthesis materials on platelet function.

Panagiotis Stathopoulos1, George Theodossiades, Constantinos Mourouzis

  • 1Department of Oral Maxillofacial Surgery K.A.T General Hospital of Athens, Greece. pan stath@yahoo.gr

The British Journal of Oral & Maxillofacial Surgery
|October 12, 2010
PubMed
Summary

Titanium maxillofacial implants do not affect platelet function. A study using the PFA-100 system found no significant differences in platelet function between patients with titanium implants and healthy controls.

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Hematology

Background:

  • Titanium implants are widely used in maxillofacial surgery and other orthopedic applications.
  • Long-term retention of these materials necessitates understanding their biological interactions.
  • Limited data exists on the impact of titanium osteosynthesis materials on platelet function.

Purpose of the Study:

  • To evaluate the effect of titanium maxillofacial osteosynthesis materials on platelet function.
  • To address the gap in English literature regarding this specific interaction.

Main Methods:

  • Platelet function was assessed in 33 patients with titanium maxillofacial implants.
  • A PFA-100 (platelet function analyser) system was utilized for testing.
  • Results were compared to a control group of 34 healthy blood donors using collagen/adrenaline and collagen/ADP agonists.

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Main Results:

  • No statistically significant differences in platelet function were observed between the patient group and the control group.
  • p-values for collagen/adrenaline and collagen/ADP were 0.1 and 0.09, respectively.
  • Titanium maxillofacial osteosynthesis materials demonstrated no significant impact on platelet function.

Conclusions:

  • Titanium maxillofacial osteosynthesis materials do not appear to significantly affect platelet function.
  • Findings suggest the safety of these materials concerning platelet hemostasis in maxillofacial surgery.