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Updated: Jun 8, 2026
07:42
Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents
Published on: April 25, 2017
Sacral neuromodulation for neurogenic lower urinary tract dysfunction: systematic review and meta-analysis
Thomas M Kessler1, David La Framboise, Sven Trelle
1Department of Urology, University of Bern, Bern, Switzerland. tkessler@gmx.ch
European Urology
|October 12, 2010
Summary
Sacral neuromodulation (SNM) shows promise for treating neurogenic lower urinary tract dysfunction (LUTD), with high success rates in permanent implantation. However, more rigorous studies are needed to confirm its safety and efficacy.
Area of Science:
- Urology
- Neurology
- Medical Devices
Background:
- Neurogenic lower urinary tract dysfunction (LUTD) presents significant treatment challenges.
- Conventional therapies for neurogenic LUTD often yield suboptimal outcomes.
- The efficacy of sacral neuromodulation (SNM) in neurogenic LUTD remains unclear.
Purpose of the Study:
- To systematically evaluate the efficacy and safety of sacral neuromodulation (SNM) for neurogenic lower urinary tract dysfunction (LUTD).
Main Methods:
- A comprehensive literature search was conducted across PubMed, EMBASE, and ScienceDirect.
- Studies reporting on the efficacy and/or safety of SNM in patients with neurogenic LUTD were included.
- Bayesian random-effects meta-analysis was employed to pool data from 26 studies involving 357 patients.
Main Results:
- Pooled success rates for SNM were 68% during the test phase and 92% for permanent implantation.
- The pooled adverse event rate was 0% for the test phase and 24% for permanent SNM.
- Mean follow-up duration was 26 months, with evidence levels ranging from 2b to 4.
Conclusions:
- SNM demonstrates potential effectiveness and safety in treating neurogenic LUTD.
- Current evidence is based on a limited number of patients and exhibits significant heterogeneity.
- Further well-designed, adequately powered randomized controlled trials are essential to support widespread SNM adoption for neurogenic LUTD.
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