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Related Experiment Video

Updated: Jun 8, 2026

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

Published on: May 9, 2021

[Comparison between two analgesic protocols on IVF success rates].

O Mialon¹, J Delotte, P Lehert

¹Service de gynécologie-obstétrique-reproduction et de médecine fœtale, hôpital de l'Archet, CHU de Nice, 2, route Saint-Antoine-de-Ginestière, 06200 Nice, France. omialon@free.fr

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction

|October 12, 2010

Summary

This summary is machine-generated.

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In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Pain management before egg retrieval using NSAIDs is safe, but its effect on in vitro fertilization (IVF) outcomes is unclear. This study found no significant impact of different analgesic protocols on IVF success rates.

Area of Science:

Reproductive Endocrinology
Anesthesiology
In Vitro Fertilization

Background:

Analgesic protocols, particularly NSAIDs, are generally well-tolerated for pain management during follicular puncture under local anesthesia.
The impact of various analgesic regimens on the success rates of in vitro fertilization (IVF) remains incompletely understood.

Purpose of the Study:

To evaluate the influence of two distinct analgesic protocols on IVF outcomes.
To compare patient comfort and IVF success rates between paracetamol/alprazolam and nefopam/ketoprofen regimens.

Main Methods:

A retrospective monocentric study design was employed, comparing two consecutive patient cohorts.
Patients received either a paracetamol/alprazolam (P/A) protocol or a nefopam/ketoprofen (N/K) protocol prior to follicular puncture.

Related Experiment Videos

Last Updated: Jun 8, 2026

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

Published on: May 9, 2021

Main Results:

No statistically significant differences were observed in biochemical pregnancy rates or other key IVF outcomes between the P/A and N/K groups.
Both analgesic protocols were found to be well-tolerated, with no adverse effects on fertilization or implantation.

Conclusions:

The nefopam/ketoprofen (N/K) analgesic protocol can enhance patient comfort during follicular puncture.
The N/K protocol does not compromise, and may potentially improve, in vitro fertilization success rates compared to the P/A protocol.