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Published on: September 17, 2016
Simplicity and complexity in the cyanobacterial circadian clock mechanism
Guogang Dong1, Yong-Ick Kim, Susan S Golden
1Center for Chronobiology, University of California - San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0116, United States. guogang.dong@gmail.com
None:
The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is built on a three-protein central oscillator that can be reconstituted in vitro, a redox-sensitive input for synchronization with the environment, and a bacterial two-component signal transduction pathway for global transcriptional regulation. This review covers the most recent progress in our understanding of the biological and biochemical mechanism of this bacterial clock, such as the discovery of a quinone-binding activity of the oscillator protein KaiA, the molecular mechanism of circadian control of cell division, and the global control of gene expression via modulation of DNA topology.
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