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Updated: Jun 8, 2026

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
Published on: June 14, 2015
Slime method: modified hemostatic technique of fibrin glue in major cardiothoracic surgery
Tsutomu Matsushita1, Shinsuke Masuda, Tomoya Inoue
1Department of Cardiovascular Surgery, Maizuru Mutual Hospital, Maizuru, Kyoto, 625-8585, Japan. atmatsu@tokyonet.com.au
Abstract:
Surgical bleeding from anastomoses due to systemic heparinization or prolonged extracorporeal circulation, which is more effectively controlled with topical hemostatic agents than with sutures, has been one of the major problems in cardiovascular surgery. We describe a novel hemostatic technique using fibrin glue. Briefly, the two components of fibrinogen and thrombin solutions are mixed and put over the bleeding point immediately after the glue has become a viscous gel. Within a minute of local compression, the glue sets well enough to stop the bleed.
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