Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Assembly of Signaling Complexes

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...

Interactions Between Signaling Pathways

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

Structural Protein Function

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...

Structural Protein Function

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...

Signal Transduction: Overview

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Protein Engineering of a Genetically Encodable Biosensor for Wastewater Detection of Profen NSAIDs.

Biotechnology and bioengineering·2026

Same author

Protein engineering of a genetically encoded biosensor for wastewater detection of profen NSAIDs.

bioRxiv : the preprint server for biology·2026

Same author

Atypical GPCR Activation Resolved by Nanobody Engineering.

bioRxiv : the preprint server for biology·2026

Same author

Explaining how mutations affect AlphaFold predictions.

bioRxiv : the preprint server for biology·2026

Same author

Computational design of dynamic biosensors for emerging synthetic opioids.

Nature communications·2026

Same author

Biosafety assessment of engineered CCL20 locked dimers in vivo.

Cell biology and toxicology·2025

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

Structural and functional insights into core ABA signaling.

Joshua J Weiner¹, Francis C Peterson, Brian F Volkman

¹Department of Biochemistry and Center for Eukaryotic Structural Genomics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Current Opinion in Plant Biology

|October 12, 2010

Summary

This summary is machine-generated.

Recent advances reveal how abscisic acid (ABA) receptors PYR1, PYL1, and PYL2 act as switches. These ABA receptors inhibit protein phosphatases, controlling key plant stress responses.

More Related Videos

Assessing Activity-based Anorexia in Mice

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons

Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons

Published on: March 8, 2010

Related Experiment Videos

Last Updated: Jun 8, 2026

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Published on: May 10, 2019

Assessing Activity-based Anorexia in Mice

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons

Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons

Published on: March 8, 2010

Area of Science:

Plant biology
Molecular signaling
Biochemistry

Background:

Abscisic acid (ABA) is a critical plant hormone regulating stress responses.
Understanding ABA perception and signaling is key to plant adaptation.
Recent years have seen significant breakthroughs in ABA signaling research.

Purpose of the Study:

To summarize recent major advances in abscisic acid (ABA) signaling.
To elucidate the mechanism of ABA perception and signaling at atomic resolution.
To highlight the core ABA signaling pathway.

Main Methods:

Structural biology (atomic resolution)
Biochemical assays
Analysis of protein-protein interactions

Main Results:

ABA receptors (PYR1, PYL1, PYL2) function as allosteric switches.
These receptors inhibit type 2C protein phosphatases (PP2Cs) upon ABA binding.
A core signaling pathway involving SnRK2 kinases and downstream targets (ABFs, SLAC1) was elucidated.

Conclusions:

ABA receptors directly link ABA perception to downstream signaling.
The identified pathway regulates crucial plant responses to environmental stress.
Atomic-level insights provide a mechanistic understanding of ABA signaling.