Related Experiment Video
Updated: Jun 8, 2026

Cultivation Methods of Spirochetes from Borrelia burgdorferi Sensu Lato Complex and Relapsing Fever Borrelia
Published on: November 25, 2022
Whole-genome sequences of thirteen isolates of Borrelia burgdorferi
Steven E Schutzer1, Claire M Fraser-Liggett, Sherwood R Casjens
1Department of Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07103, USA. schutzer@umdnj.edu
Abstract:
Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease. Because a single genome sequence is not sufficient to understand the relationship between genotypic and geographic variation and disease phenotype, we determined the whole-genome sequences of 13 additional B. burgdorferi isolates that span the range of natural variation. These sequences should allow improved understanding of pathogenesis and provide a foundation for novel detection, diagnosis, and prevention strategies.
Related Concept Videos
Bacterial Phylum Spirochaetes
Modern Molecular Taxonomy
Applications of Molecular Taxonomy

