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Related Experiment Video

Updated: Jun 8, 2026

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

Brown adipose tissue in humans.

¹Department of Medical and Clinical genetics, Göteborg University, Göteborg, Sweden. sven.enerback@medgen.gu.se

International Journal of Obesity (2005)

|October 12, 2010

Summary

Brown adipose tissue (BAT) combats obesity by increasing energy expenditure through adaptive thermogenesis, mediated by uncoupling protein-1 (UCP1). UCP1 activation protects against diet-induced obesity and related metabolic disorders.

Area of Science:

Metabolic research
Obesity research
Adipose tissue biology

Background:

Obesity is a global health crisis, preceding severe diseases like heart disease and diabetes.
Current effective treatments like bariatric surgery are limited by cost and accessibility.
Increasing energy expenditure is a potential therapeutic strategy for obesity.

Purpose of the Study:

To investigate the role of brown adipose tissue (BAT) in combating obesity and related metabolic dysfunction.
To explore the mechanism of adaptive thermogenesis and the function of uncoupling protein-1 (UCP1) in energy expenditure.

Main Methods:

Studied mice lacking the UCP1 gene to assess its role in thermoregulation and obesity.
Examined the impact of BAT activity on diet-induced obesity, insulin resistance, and type 2 diabetes in mice.

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Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans

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Analyzed the prevention of ectopic triglyceride accumulation in non-adipose tissues.

Main Results:

Mice lacking UCP1 exhibit impaired cold tolerance and are prone to obesity.
BAT was shown to protect against diet-induced obesity, insulin resistance, and type 2 diabetes in mice.
This protection is linked to the prevention of excessive triglyceride storage in the liver and muscles.

Conclusions:

Brown adipose tissue (BAT) plays a crucial role in energy homeostasis and metabolic health.
UCP1-mediated adaptive thermogenesis is a key mechanism by which BAT combats obesity.
Targeting BAT could offer novel therapeutic strategies for obesity and type 2 diabetes.