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Updated: Jun 8, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
Nosocomial infections and multidrug-resistant bacterial organisms in the pediatric intensive care unit
Eric J McGrath1, Basim I Asmar
1The Carmen and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, USA. emcgrath@dmc.org
Insights
Multidrug-resistant infections in Pediatric Intensive Care Units (PICUs) are rising. This review covers infection types, resistant pathogens, and control strategies to combat these serious nosocomial infections.
Area of Science:
- Pediatric Intensive Care Medicine
- Infectious Diseases
- Microbiology
Background:
- Nosocomial infections pose a significant threat in Pediatric Intensive Care Units (PICUs).
- The increasing prevalence of multidrug-resistant organisms (MDROs) complicates patient management and outcomes.
Purpose of the Study:
- To review current international literature on nosocomial infections in PICUs.
- To identify common infection types, emerging resistant pathogens, and effective control measures.
Main Methods:
- Systematic literature review of nosocomial infections in PICU settings.
- Analysis of data on infection types, causative agents, and resistance patterns.
- Summary of infection control and prevention strategies.
Main Results:
- Common PICU infections include CLABSI, VAP, UTIs, GI infections, and surgical site infections.
- Key MDROs identified: MRSA, VRE, C. difficile, ESBL-GNRs, KPC, and MDR Acinetobacter baumannii.
- Effective infection control methods are crucial for MDRO management.
Conclusions:
- Addressing rising MDROs in PICUs requires a comprehensive approach.
- Enhanced infection control and prevention strategies are vital to reduce nosocomial infections.
- Continued international collaboration is needed to combat antimicrobial resistance in pediatric critical care.
Abstract:
Nosocomial infections in Pediatric Intensive Care Units (PICUs) caused by multidrug-resistant bacterial organisms are increasing. This review attempts to report on significant findings in the current literature related to nosocomial infections in PICU settings with an international perspective. The types of nosocomial infections are addressed, including catheter-related bloodstream infections, ventilator-associated pneumonia, urinary tract infections, gastrointestinal infections and post-surgical wound infections. A review of emerging resistant bacterial pathogens includes methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus sp., Clostridium difficile, extended-spectrum β-lactamase producing Gram-negative organisms, Klebsiella pneumoniae carbapenemase-producing strains and multi-drug resistant Acinetobacter baumannii. Basic and enhanced infection control methods for the management and control of multidrug-resistant organisms are also summarized with an emphasis on prevention.
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