Related Experiment Video
Updated: Jun 8, 2026
Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
Published on: September 25, 2018
[Study on the transcript expression of p73 gene in human non-small cell lung cancer tissues.]
1Department of Thoracic Surgery , Daping Hospital , The Third Military Medical University , Chongqing 400042 , P. R. China.
Background:
To explore the relationship among the p73 gene transcript expression and the oncogenesis , development of human non-small cell lung cancer (NSCLC) .
Methods:
The expression of p73 mRNA was detected in 32 human NSCLC tissues , para-cancer tissues , 7 lung benign lesion tissues and matched non-cancer lung tissues by semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR) .
Results:
Overexpression of p73 mRNA was found in 28/ 32 NSCLC tissues. The positive expression rate of the p73 mRNA in the cancer tissues was significantly higher than that in the para-cancer tissues and benign lesion tissues either ( P < 0. 01) . No significant relationship was observed among p73 expression and differentiated grades , histoclassification and P-TNM stages of the cancer ( P > 0. 05) .
Conclusions:
The results suggest that there is an overexpression of p73 mRNA in lung cancer tissues and it may paly an important role in the tumorigenesis and development in NSCLC.
