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Published on: March 24, 2015
[Expression of HLA-DR antigen in lung cancer.]
1The Institute of Respiratory Disease , China Medical University , Shenyang 110001 , P. R. China.
Background:
To investigate the expression of HLA-DR antigen in lung cancer and the relationship with histologic types and lymphocyte infiltration around tumor cells.
Methods:
Cancer tissues from 56 patients with lung cancer were examined immunohistochemically , while the expression of HLA-DR antigen induced by recombinant IFN-gamma in two cells lines of lung cancer was examined with flowcytometry.
Results:
Twenty two cases of adenocarcinoma (22/ 29 ,76 %) and two cases of squamous cell carcinoma (2/ 24 , 8 %) were positive for the HLA-DR antigen , and no positive expression showed in 3 cases of small cell carcinoma. The positive expression rate in adenocarcinoma was significantly higher than that in squamous cell carcinoma ( P < 0. 05) . Marked lymphocyte infiltration was seen around the tumor cells in HLA-DR antigen positive patients. In vitro , IFN-gamma could stimulate HLA-DR antigen expression in two lung cancer cell lines , which was dose-dependent.
Conclusions:
The expression of HLA-DR antigen in lung cancer is correlated with histologic types and lymphocyte infiltration around the cancer cells , and may influence the host immune response to tumor.
