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[Formulation optimization of gel matrix of Saussurea involucrate by orthogonal design]
Xianhui Huang1, Jianguo Xing, Xinchun Wang
1College of Pharmacy, Shihezi University, Xinjiang 832002, China.
Objective:
To optimize the formulation of gel matrix of Saussurea involucrate.
Method:
The formulation of gel containing carbopol, azone, trimethylene glycol and alcohol was optimized by orthogonal design with evaluation indexes such as consistency in room temperature, consistency of average temperature of skin, yield value and rheopexy in room temperature.
Result:
The optimal proportion of matrix components was made from carbopol-azone-trimethylene glycol-absolute alcohol (2. 0: 2. 0:15.0 : 30.0).
Conclusion:
The optimal formulation of S. involucrate gel based the optimal formulation is well-distributed and transparent, it has proper consistency and well rheopexy.
