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Lipid lymphocyte chemoattractants in psoriasis.
1Institute of Dermatology, United Medical School, Guy's Hospital, London, England.
Prostaglandins
|December 1, 1990
Summary
Researchers identified specific lipid compounds in psoriatic skin lesions that attract lymphocytes. The major identified compound, 12-(R)-hydroxy-5,8,10,14-eicosatetraenoic acid (12[R]-HETE), may contribute to psoriasis pathogenesis.
Area of Science:
- Dermatology
- Immunology
- Lipid Biochemistry
Background:
- Lymphocyte infiltrates are characteristic of psoriatic skin lesions.
- Certain hydroxylated arachidonic acid metabolites in psoriatic skin attract lymphocytes.
Purpose of the Study:
- To identify predominant lipid lymphocyte chemoattractants in psoriasis.
- To investigate the role of these lipids in psoriatic lesion pathogenesis.
Main Methods:
- Lipid extracts from lesional and normal psoriatic skin stratum corneum were analyzed.
- High-performance liquid chromatography (HPLC) was used for purification.
- Biological and chromatographic properties were used for identification.
Main Results:
- Lipid extracts from psoriatic stratum corneum showed significant lymphocyte chemoattractant activity, unlike normal skin.
- At least two lipid chemoattractants were purified from psoriatic lesions.
- 12-(R)-hydroxy-5,8,10,14-eicosatetraenoic acid (12[R]-HETE) was identified as a major chemoattractant.
Conclusions:
- Specific lipid chemoattractants, notably 12[R]-HETE, are present in psoriatic skin lesions.
- These lipids may play a role in the development of lymphocyte infiltrates in psoriasis.