[Preliminary clinical application of cancellous granule-type calcium phosphate cement]

To investigate the clinical efficacy of the cancellous granule-type calcium phosphate cement in repair bone defect.

Between July 2008 and July 2009, 35 patients (42 limbs) with fractures, nonunion, and benign bone tumor were treated with cancellous granule-type calcium phosphate cement. There were 32 males and 3 females, with an age range from 9 to 73 years (median, 41 years), including 24 limb fractures (19 cases), 4 osteotomy for deformity of ulna and radius (2 cases), 2 femur intertrochanteric bony cysts (2 cases), 3 enchondroma (3 cases), 5 bone defect at donor ilium (5 cases), 3 nonunion (3 cases), and 1 lumbar spinal stenosis (1 case). The size of bone defect was 1-5 cm. Bone defect was repaired with cancellous granule-type calcium phosphate cement (1-5 g).

All cases were followed up 8-23 months (13.7 months on average). Thirty-nine incisions (32 cases) healed by first intention and the suture was removed after 10-14 days. Incision dehiscence occurred in 2 cases, and wounds healed after second debridement and removal of artificial bone. Exudation of incision occurred in 1 case, and wound healed after symptomatic treatment. No local red swelling, higher temperature, maculopapular, and ulceration of skin occurred at implantation site. X-ray films showed that bone graft fusion was achieved and bone defect was radically repaired at 6 months after operation and artificial bone was absorbed completely at 12 months.

Cancellous granule-type calcium phosphate cement can be used as a new graft bone material, which is suitable for defect filling after traumatic fracture, benign bone tumors, and iliac bone donor.