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CD36 as a multiple-ligand signaling receptor in atherothrombosis

R Nergiz-Unal1, T Rademakers, J M E M Cosemans

  • 1Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands.

Cardiovascular & Hematological Agents in Medicinal Chemistry
|October 14, 2010
PubMed

Insights

CD36, a cell surface glycoprotein, interacts with ligands like oxidized lipoproteins to influence cellular responses. Understanding its signaling pathways offers potential therapeutic targets for atherothrombosis.

Area of Science:

  • Cardiovascular Biology
  • Molecular Cell Biology
  • Immunology

Background:

  • CD36 is a cell surface glycoprotein found on various cardiovascular cells, including platelets and monocytes.
  • Its precise role in cellular function has been historically unclear despite its widespread expression.

Purpose of the Study:

  • To review the known functions of CD36.
  • To explore how CD36 mediates cellular responses through ligand interactions.
  • To discuss the intracellular signaling pathways activated by CD36.

Main Methods:

  • Literature review of studies on CD36 function and signaling.
  • Analysis of CD36 interactions with ligands such as thrombospondin-1, oxidized lipoproteins, and fatty acids.
  • Examination of CD36's role in intracellular signaling pathways like Src-family kinases, MAP kinases, NFκB, and Rho.

Main Results:

  • CD36 binds to multiple ligands, influencing cellular behavior.
  • Its transmembrane structure facilitates intracellular signaling, potentially with co-receptors.
  • Evidence links CD36 to the activation of Src-family kinases, MAP kinases, NFκB, and Rho pathways.

Conclusions:

  • CD36 plays a significant role in cellular responses within the cardiovascular system.
  • Its involvement in key signaling cascades highlights its functional importance.
  • CD36 presents a promising therapeutic target for modulating platelet and monocyte/macrophage activity to combat atherothrombosis.

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