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Updated: Jun 8, 2026

Semi-quantitative Detection of RNA-dependent RNA Polymerase Activity of Human Telomerase Reverse Transcriptase Protein
Published on: June 12, 2018
[Expression of telomerase activity in human lung cancer.]
1Department of Respiratory Diseases , Anhui Provincial Hospital , Hefei , Anhui 230001 , P. R. China.
Background:
To investigate the expression of telomerase activity in lung cancer tissue and the correlation with the oncogenesis , progression and metastasis of lung cancer.
Methods:
Telomerase activity in specimens obtained by fiberbrochoscopy from 29 patients with suspected lung cancer was detected by polymerase chain reaction-ELISA.
Results:
The telomerase activity was positive in 18 cases of primary lung cancer and the positive rate was 81. 81 %(18/ 22) . Two of other seven specimens were positive for telomerase activity. Twelve lung cancer cases with lymph node metastasis showed positive expression , whereas only 6 of 10 cases without lymph node metastasis showed positive expression.
Conclusions:
Telomerase activity may be useful both as a diagnostic marker to detect the existence of lung cancer and as a potential of high risk for lymph node metastasis.
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