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Updated: Jun 8, 2026

Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
Published on: April 1, 2019
[Experimental circumferential tracheal replacement with rib and costal muscle ring in dog.]
1Department of Thoracic and Cardiac Surgery , Affiliated Hospital , Chengde Medical College , Chengde , Hebei 067000 , P. R. China.
Background:
To evaluate the feasibility of using vascularized rib and costal muscle ring to repair large circumferential defect of thoracic trachea in dog.
Methods:
Eighteen adult mongrel dogs were used in this study. The third rib with adjacent intercostal muscles was engineered to a ring with vascular pedicle , which replaced five or eight rings of trachea.
Results:
Eleven of eighteen dogs were alive after operation , and the longest one had survived for 14 months. These dogs were active , although a slight stricture at the newly formed trachea was found. Microscopic examination showed the trachea had good blood supply , and the substitution of pleural epithelium by ciliated epithelium was observed.
Conclusions:
Circumferential tracheal replacement with vascularized rib and intercostal muscle ring is easily managed and has less complications. The results suggest that this technique might be clinically used in the future.
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