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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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Published on: October 10, 2025

[Clinicopathological Characteristics of ROS1-positive 
Non-small Cell Lung Cancer Based on Next-generation

Lina Gao1, Li Sun1, Weihua Li1

  • 1Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, 
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|July 15, 2026
PubMed
Summary

Immunohistochemistry (IHC) shows 100% sensitivity for detecting ROS1 gene fusions in non-small cell lung cancer (NSCLC), making it a valuable initial screening tool. Next-generation sequencing (NGS) is recommended for confirming strong IHC results and identifying fusion partners.

Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Pathology
Keywords:
Fluorescence in situ hybridizationHistopathologyImmunohistochemistryLung neoplasmsNext-generation sequencingROS1 gene fusion

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