Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antifungal Agents

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

Candidiasis

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Impact of Aging Oral Health on Long COVID-19.

Journal of dental research·2025

Same author

Cellular senescence and aging.

Oral diseases·2016

Same author

Rechargeable anticandidal denture material with sustained release in saliva.

Oral diseases·2016

Same author

Anticandidal activity and biocompatibility of a rechargeable antifungal denture material.

Oral diseases·2012

Same author

Cellular signals underlying β-adrenergic receptor mediated salivary gland enlargement.

Differentiation; research in biological diversity·2011

Same author

Salivary secretion, mucin concentrations and Candida carriage in HIV-infected patients.

Oral diseases·2009

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

Published on: December 26, 2016

Rechargeable infection-responsive antifungal denture materials.

Z Cao¹, X Sun, C-K Yeh

¹Biomedical Engineering Program, University of South Dakota, 4800 N Career Ave., Sioux Falls, SD 57107, USA.

Journal of Dental Research

|October 14, 2010

Summary

This summary is machine-generated.

New denture materials fight fungal infections like Candida-associated denture stomatitis (CADS). These rechargeable materials release antifungal drugs over time, offering a promising solution for managing oral infections.

Related Experiment Videos

Last Updated: Jun 8, 2026

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition

Published on: December 26, 2016

Area of Science:

Biomaterials Science
Mycology
Dental Materials

Background:

Candida-associated denture stomatitis (CADS) presents a significant clinical challenge.
Current management strategies for CADS may have limitations.

Purpose of the Study:

To develop novel, rechargeable, infection-responsive antifungal denture materials.
To evaluate the sustained release and efficacy of bound antifungal drugs.

Main Methods:

Polymethacrylic acid (PMAA) was covalently bound to denture resins.
Cationic antifungal drugs (miconazole, chlorhexidine digluconate) were ionically bound to PMAA-resin composites.
Antimicrobial activity and drug release kinetics were assessed under different pH conditions.
Rechargeability of drug-depleted resins was investigated using EDTA treatment.

Main Results:

Antifungal activity was sustained for extended periods (weeks to months).
Drug release was significantly faster at acidic pH (5) compared to neutral pH (7).
Drug-loaded resins were successfully recharged after drug depletion.

Conclusions:

The developed PMAA-based denture materials demonstrate sustained antifungal properties.
The rechargeable nature of these materials offers potential for long-term management of CADS.
These findings suggest clinical applicability for managing CADS and other oral infections.