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Observations with trimethoprim tablet used in urinary tract infections
1Department of Urology, Municipal István Hospital and Outpatient Clinic, Budapest.
Abstract:
Trimethoprim monotherapy was applied in 50 cases. Recovery was obtained in 18 patients (36%), improvement in 15 patients (30%), and in 17 cases (34%) no change was observed in response to the therapy. Trimethoprim therapy may be successfully used in acute and chronic cystitis and urethritis-especially in E. coli infections. The therapy is significantly less effective in urinary tract infections caused by other Gram-negative and Gram-positive micro-organisms. In the course of drug therapy only a few side-effects were observed.
Insights
Trimethoprim monotherapy effectively treated acute and chronic cystitis and urethritis, particularly for E. coli infections. While less effective for other bacteria, it showed minimal side effects in patients.
Area of Science:
- Urology
- Infectious Diseases
- Pharmacology
Background:
- Urinary tract infections (UTIs) are common, necessitating effective antimicrobial therapies.
- Bacterial resistance and treatment efficacy are key concerns in managing UTIs.
- Trimethoprim is an antibiotic frequently used for bacterial infections.
Purpose of the Study:
- To evaluate the efficacy and safety of trimethoprim monotherapy in treating urinary tract infections.
- To determine the effectiveness of trimethoprim against specific uropathogens, including E. coli.
Main Methods:
- A cohort of 50 patients with UTIs received trimethoprim monotherapy.
- Treatment outcomes were categorized as recovery, improvement, or no change.
- Efficacy was assessed based on the causative microorganisms, focusing on E. coli.
Main Results:
- 36% of patients achieved full recovery, while 30% showed improvement.
- No significant change was observed in 34% of cases.
- Trimethoprim demonstrated high efficacy against E. coli but was less effective against other Gram-negative and Gram-positive bacteria.
Conclusions:
- Trimethoprim monotherapy is a viable treatment option for acute and chronic cystitis and urethritis, especially when caused by E. coli.
- The drug is less effective for UTIs stemming from other bacterial species.
- Trimethoprim exhibited a favorable safety profile with few observed side effects.