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Updated: Jun 8, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Giant melanotrichoblastoma.

Deok-Woo Kim¹, Jeong Hyeon Lee, Insun Kim

¹Department of Plastic Surgery, Medical Center, Korea University Medical College, 126-1 5 ga Anam-dong, Sungbuk-ku, Seoul, Korea.

The American Journal of Dermatopathology

|October 14, 2010

Summary

This study describes a rare giant melanotrichoblastoma, a benign skin tumor. The tumor contained numerous dendritic melanocytes, confirmed by immunohistochemical staining, aiding diagnosis.

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Area of Science:

Dermatopathology
Oncology
Histology

Background:

Trichoblastomas are benign skin neoplasms originating from hair follicle germinative cells.
Various subtypes exist, including pigmented, melanotrichoblastoma, subcutaneous, and giant variants.

Observation:

A rare case of a pigmented trichoblastoma with abundant dendritic melanocytes is presented.
The tumor, a 6 cm subcutaneous mass on a 51-year-old man's back, showed numerous Melan A-positive dendritic melanocytes.
Immunohistochemical analysis revealed HMB45 positivity and focal S-100 protein positivity in these melanocytes.

Findings:

The presence of abundant dendritic melanocytes within the epithelial components of the trichoblastoma was confirmed.
Immunohistochemical markers (Melan A, HMB45, S-100) were crucial in identifying and characterizing these melanocytes.
The diagnostic criteria supported classification as a giant melanotrichoblastoma.

Implications:

This case expands the understanding of trichoblastoma variants and their histopathological features.
Highlights the importance of immunohistochemistry in differentiating benign skin tumors with melanocytic components.
Contributes to the literature on rare cutaneous neoplasms and their accurate diagnosis.