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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Special Features of Adaptive Immunity01:20

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Related Experiment Video

Updated: Jan 12, 2026

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
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A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

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Plasmacytoid dendritic cells in tolerance.

Eric Gehrie1, William Van der Touw, Jonathan S Bromberg

  • 1Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY, USA.

Methods in Molecular Biology (Clifton, N.J.)
|October 14, 2010
PubMed
Summary
This summary is machine-generated.

Plasmacytoid dendritic cells (pDCs) can induce immune tolerance by promoting regulatory T-cell (Treg) development. This study provides tools to investigate pDC function and Treg interactions in sterile inflammation.

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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
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Last Updated: Jan 12, 2026

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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are key antigen-presenting cells (APCs) that dictate immune responses towards immunity or tolerance.
  • Murine plasmacytoid DCs (pDCs) are a distinct subset characterized by specific surface markers and dual roles in immunity and tolerance.

Purpose of the Study:

  • To provide tools for studying plasmacytoid dendritic cell (pDC) development from bone marrow cultures.
  • To investigate pDC antigen presentation properties and their interactions with regulatory T-cells (Tregs) in a tolerogenic context.

Main Methods:

  • Bone marrow cultures for pDC development.
  • Analysis of pDC antigen presentation capabilities.
  • Assessment of pDC-Treg interactions in sterile inflammation models.

Main Results:

  • pDCs secrete type I interferon (IFN) upon viral stimulation, acting as immunogenic sentinels.
  • pDCs express IDO, ICOS-L, and PD-L1, promoting Treg development and suppressing self-reactive cells.
  • pDC-mediated Treg induction involves the presentation of antigenic peptides via MHC class I and II.

Conclusions:

  • pDCs possess both immunogenic and tolerogenic functions.
  • The tools developed facilitate the study of pDC-Treg interactions in tolerance induction.
  • Understanding pDC roles is crucial for modulating immune responses in inflammatory and autoimmune settings.