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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
Immunosuppressive mechanisms during viral infectious diseases
Ghanashyam Sarikonda1, Matthias G von Herrath
1Department of Developmental Immunology-3, Diabetes Center of San Diego, La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA.
Methods in Molecular Biology (Clifton, N.J.)
|October 14, 2010
Summary
Viruses persist by evading immune responses. Blocking immune regulation, like IL-10 and PD-1, can restore T-cell function and potentially eliminate persistent viral infections.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- Persistent viral infections rely on viruses exploiting host immune evasion strategies.
- Immune responses must be downregulated post-viral clearance via immunoregulation.
- Interleukin-10 (IL-10) and Programmed cell Death protein 1 (PD-1) are key regulators of antiviral immunity.
Purpose of the Study:
- To investigate the role of immune regulatory mechanisms in persistent viral infections.
- To explore the potential of neutralizing negative immune regulation for viral clearance.
Main Methods:
- Analysis of viral persistence mechanisms in host immune systems.
- Review of studies on IL-10 and PD-1 in antiviral immune responses.
- Examination of T-cell function restoration in chronic viral infections.
Main Results:
- Viruses like LCMV, HIV, and HCV demonstrate immune evasion through host system exploitation.
- Functionally impaired T-cells in chronic infections can be reactivated to restore effector functions.
- Negative immune regulation appears crucial for maintaining viral persistence.
Conclusions:
- Neutralizing negative immune regulation may preserve effector T-cell responses against viruses.
- Targeting IL-10 and PD-1 pathways could offer a strategy to eliminate persistent viral infections.
- Restoring T-cell function presents a promising therapeutic avenue for chronic viral diseases.
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