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Updated: Jul 25, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 16, 2013
[Significance of Oct-4's expression in thyroid neoplasm]
1Department of Otorhinolaryngology Head and Neck Surgery, Renji Hospital, Institute of Otorhinolaryngology, School of Medicine, Shanghai Jiaotong University, Shanghai, 200001, China.
Objective:
To discuss the meanings of Oct-4's expression in thyroid adenoma, thyroid papillary carcinoma, thyroid follicular carcinoma, and medullary thyroid carcinoma.
Method:
We examined the expression of Oct-4 in 15 thyroid adenoma, 30 thyroid papillary carcinomas, 2 thyroid follicular carcinomas, and 3 medullary thyroid carcinomas using immunofluorescence.
Result:
Oct-4 expression was observed in all the thyroid-related diseases mentioned above. In thyroid papillary carcinomas, the expression of Oct-4 were higher than that in thyroid adenoma, and had no obvious relationship with the patients age, sex, the size and location of tumor and tumor metastasis.
Conclusion:
The formation of the thyroid carcinomas may be concerned with the stem cells in thyroid. There are more stem cells in medullary thyroid carcinomas and follicular carcinomas.
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