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Updated: Jun 8, 2026

Immunolabelling Myofiber Degeneration in Muscle Biopsies
Published on: December 5, 2019
Necrotizing vacuolar myopathy presenting with recurrent myoglobinuria
Ramachandiran Nandhagopal1, Abdullah Al-Asmi, Gujjar R Arunodaya
1Departments of Medicine (Neurology Unit), College of Medicine and Health Sciences, Al-Khod, Muscat, Oman. rnandagopal@yahoo.com
Abstract:
Myoglobinuria occurs in a variety of systemic and neurological disorders and can pose diagnostic challenges. We report on a 23-year-old man in whom recurrent myoglobinuria was observed due to necrotizing vacuolar myopathy confirmed on muscle biopsy. Histopathologically the intramuscular vacuoles lacked the typical findings reported in vacuolar myopathy due to disorders of glycogen and lipid metabolism. We discuss the management approach to recurrent myoglobinuria. Recurrent myoglobinuria in the absence of toxin or drug exposure and seizure is more often due to primary muscle disease. Recognizing the presence of myoglobinuria and the proximate cause is essential in preventing the development of renal dysfunction and the future recurrence of symptoms.
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