Importance of enantiomeric purity and its control by thin-layer chromatography

Methods for the direct resolution of enantiomers are important and are necessary for pharmaceutical and biomedical analysis, synthetic and mechanistic studies and various other fields. The present paper deals with the results of recent approaches, such as ligand exchange, ion exchange and steric interactions, providing direct resolution of enantiomers of a variety of compounds by thin-layer chromatography. General aspects of various methods for analysis of enantiomeric purity and resolution have been compared.