Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.2K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.2K
Pigmentation01:19

Pigmentation

4.0K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
4.0K
Abnormal Proliferation02:23

Abnormal Proliferation

5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.6K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.6K
Genetic Lingo01:11

Genetic Lingo

113.4K
Overview
113.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring AI as a Diagnostic Tool in Medical Imaging for Dermatopathological Diseases.

Indian journal of dermatology·2026
Same author

Noise matters: assessing non-auditory health impacts of occupational noise exposure among factory workers.

Frontiers in public health·2026
Same author

Adapting a commercial sample extraction protocol for biosafety level 3/4 compatible plasma metabolomics analysis.

Journal of mass spectrometry and advances in the clinical lab·2025
Same author

Positioning, navigation, and timing on the Moon and Mars with galactic cosmic rays.

iScience·2025
Same author

Efficacy of Cognitive Interventions in Mild Cognitive Impairment due to Alzheimer's Disease- An Open-Labelled Exploratory Analysis.

Neurology India·2024
Same author

Making a serious game (gamification) for generation Z medical students to learn, teach, and assess medical Physiology.

Journal of education and health promotion·2024
Same journal

Severe combined immunodeficiency (SCID) with pigmentary mosaicism: A coincidental occurrence in a child.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Agminated multifocal eruptive lobular capillary haemangiomas - An uncommon presentation.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Patch testing in India: Are we missing clinically relevant allergens?

Indian journal of dermatology, venereology and leprology·2026
Same journal

Double-loading technique for improved suspension retention on the recipient site in non-cultured epidermal cell suspension (NCES).

Indian journal of dermatology, venereology and leprology·2026
Same journal

Late-onset metastatic melanoma arising from a medium-sized congenital melanocytic naevus.

Indian journal of dermatology, venereology and leprology·2026
Same journal

Custom-compounded glycine-proline jelly for ulcers in prolidase deficiency.

Indian journal of dermatology, venereology and leprology·2026
See all related articles

Related Experiment Video

Updated: Jan 4, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.5K

Malignant blue nevus.

S Krishnan1, D P Yesudian, M Jayaraman

  • 1Department of Dermatology, Madras Medical College and Government General Hospital, Madras, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 15, 2010
PubMed
Summary
This summary is machine-generated.

Malignant blue nevus, a rare form of melanoma, can arise from benign melanocytes. This case highlights a fatal outcome due to ulceration and metastasis of a blue nevus on the foot.

More Related Videos

Zebrafish Model of Neuroblastoma Metastasis
05:20

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

3.1K
A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

16.4K

Related Experiment Videos

Last Updated: Jan 4, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.5K
Zebrafish Model of Neuroblastoma Metastasis
05:20

Zebrafish Model of Neuroblastoma Metastasis

Published on: March 14, 2021

3.1K
A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

16.4K

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Blue nevus is a benign proliferation of dermal melanocytes.
  • Malignant transformation of blue nevus is exceptionally rare.
  • It is considered a subtype of malignant melanoma.

Purpose of the Study:

  • To report a rare case of malignant blue nevus.
  • To describe the clinical course and outcome.
  • To emphasize the aggressive potential of this rare condition.

Main Methods:

  • Case report of a 35-year-old male.
  • Clinical presentation of a primary lesion on the left foot.
  • Documentation of ulceration and subsequent metastasis.

Main Results:

  • The patient presented with an ulcerated blue nevus.
  • The condition progressed rapidly, leading to multiple metastases.
  • The patient ultimately succumbed to the disease.

Conclusions:

  • Malignant blue nevus, though rare, can have a poor prognosis.
  • Early recognition and understanding of its metastatic potential are crucial.
  • This case underscores the importance of vigilance in managing pigmented lesions.