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Updated: Jun 8, 2026
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
3.4 kb mitochondrial genome deletion serves as a surrogate predictive biomarker for prostate cancer in
Brian Reguly1, John P Jakupciak, Ryan L Parr
1Genesis Genomics Inc., Thunder Bay, ON;
Abstract:
Recently, we described a 3.4-kb mitochondrial genome deletion having significance for identifying malignant and benign prostate tissues (p < 0.001). This biomarker was also present in normal appearing tissue, in close proximity to a tumour indicating a "field effect." In the present study, we report 4 cases (3 malignant, 1 benign) which suggest that this field effect may occur before tumourigenesis; this effect may also identify the presence of a small tumour focus/foci, which are difficult to detect with single or multiple biopsy procedures.
