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Published on: November 21, 2013
Behavioral changes as the earliest clinical manifestation of progressive supranuclear palsy
Hyun Jeong Han1, Hyeyun Kim, Jong-Ho Park
1Department of Neurology, Myongji Hospital, College of Medicine, Kwandong University, Goyang, Korea.
Background:
The clinical and pathological heterogeneity of progressive supranuclear palsy (PSP) is well established. Even with a well-defined clinical phenotype and a thorough laboratory workup, PSP can be misdiagnosed, especially in its early stages.
Case Report:
A 52-year-old woman, who we initially diagnosed with a behavioral variant of frontotemporal dementia developed parkinsonian features, which then progressed to gait instability and gaze abnormality.
Conclusions:
We report herein a pathologically confirmed case of PSP presenting with behavioral changes including agitation and irritability, which eventually led to the cardinal symptoms of progressive supranuclear palsy.
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