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Updated: Jun 8, 2026
07:54
Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Pathophysiology of sleep-disordered breathing]
Luciana de Oliveira Palombini1
1Instituto do Sono de São Paulo, São Paulo, SP, Brasil. lpalombini@hotmail.com
Summary
During sleep, the respiratory system changes, increasing risks for breathing abnormalities. Factors like airway anatomy and genetics contribute to sleep-disordered breathing.
Area of Science:
- Respiratory Physiology
- Sleep Medicine
- Genetics
Context:
- Sleep involves significant respiratory system alterations, increasing vulnerability to abnormalities.
- Transitioning to sleep elevates upper airway resistance and impairs protective reflexes.
- Individuals with risk factors, like anatomical abnormalities, are more susceptible to sleep-disordered breathing.
Purpose:
- To explore the multifactorial causes of sleep-disordered breathing.
- To examine the role of anatomical and functional upper airway changes during sleep.
- To understand the genetic and environmental contributions to sleep-disordered breathing.
Summary:
- Sleep-disordered breathing is linked to reduced upper airway size, stemming from anatomical issues, neuromuscular alterations, and impaired airway receptors.
- Genetic predispositions and environmental factors such as allergies can increase the likelihood of developing sleep-disordered breathing.
- Compensatory mechanisms for maintaining airway patency during wakefulness are less effective during sleep, especially in at-risk individuals.
Impact:
- Highlights the complex interplay of factors contributing to sleep-disordered breathing.
- Underscores the importance of considering anatomical, genetic, and environmental influences in sleep-related respiratory disorders.
- Provides a foundation for further research into the pathophysiology and potential interventions for sleep-disordered breathing.
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