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Stuttering priapism: case report and bibliographic review
R Molina Escudero1, E Rodriguez Fernandez, E Lledo Garcia
1Urology Department, Hospital Universitario Gregorio Marañon, Madrid, Spain. robersescu@hotmail.com
Archivos Espanoles De Urologia
|October 16, 2010
Summary
Stuttering priapism, a rare condition, was effectively managed with Diazepam and Terbutaline after other treatments failed. This case highlights alternative therapeutic options for this complex erectile dysfunction.
Area of Science:
- Urology
- Andrology
- Pharmacology
Background:
- Stuttering priapism is a rare condition characterized by recurrent, prolonged erections.
- Understanding its pathophysiology involves dysregulation of erection mechanisms, particularly involving phosphodiesterase type 5 (PDE5) and cyclic guanosine monophosphate (cGMP).
Observation:
- A 25-year-old male presented with daily stuttering priapism episodes for 18 months, significantly impacting his quality of life.
- Initial treatments with Bicalutamide and Tadalafil (a PDE5 inhibitor) were ineffective.
Findings:
- Diagnostic workup, including blood tests, penile Doppler ultrasound, and selective arteriography, revealed no abnormalities.
- Successful management was achieved using a combination of Diazepam (10 mg/day) and Terbutaline (5 mg/day), leading to complete symptom resolution.
Implications:
- This case suggests that non-standard drug combinations may be effective for stuttering priapism when typical therapies fail.
- Further research is needed to establish evidence-based guidelines for managing this rare priapism variant.
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