Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

Doxorubicin-induced thymus senescence.

Rukhsana Sultana¹, Fabio Di Domenico, Michael Tseng

¹Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States. rsult2@uky.edu

Journal of Proteome Research

|October 16, 2010

Summary

Doxorubicin (DOX) chemotherapy causes thymic senescence, evidenced by thymic aging markers and altered protein expression. This study reveals DOX

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Glioblastoma-derived extracellular vesicles released after radiation promote cognitive impairment through NFκB-mediated microglial activation.

bioRxiv : the preprint server for biology·2026

Same author

Peripheral immunochemical considerations in Parkinson disease: sources, targets and crosstalk mechanisms.

Journal of translational medicine·2026

Same author

GDF-11, GDF-15, Jag-1, and leptin in neuronal-derived extracellular vesicles as aging-related biomarkers to identify individuals at risk of Alzheimer's dementia: A pilot study.

Neurobiology of disease·2026

Same author

Proteome Signature of Alzheimer-Like Phenotypes in Frontal Cortices From Young and Old Individuals With Down Syndrome.

Molecular neurobiology·2025

Same author

Insulin signaling in microglia: A metabolic switch controlling neuroinflammation and amyloid pathology in Alzheimer's disease.

Cell metabolism·2025

Same author

The double life of glucose metabolism: brain health, glycemic homeostasis, and your patients with type 2 diabetes.

BMC medicine·2024

Area of Science:

Oncology
Immunology
Toxicology

Background:

Doxorubicin (DOX) is a vital anticancer drug for solid tumors.
DOX exhibits toxicity to normal cells, including the heart, causing cardiomyopathy.
The thymus, crucial for T-cell maturation, is also affected by DOX, but its age-related degeneration complicates research.

Purpose of the Study:

To investigate the impact of Doxorubicin (DOX) on the thymus.
To understand DOX-induced changes in thymic cellularity and aging markers.
To identify proteomic alterations in the thymus following DOX treatment.

Main Methods:

In vivo administration of Doxorubicin (DOX).
Histological analysis of thymic tissue.
Proteomics analysis to assess protein expression changes.

More Related Videos

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

Induction and Validation of Cellular Senescence in Primary Human Cells

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Related Experiment Videos

Last Updated: Jun 8, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

Induction and Validation of Cellular Senescence in Primary Human Cells

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Main Results:

DOX treatment induced thymic degeneration, characterized by loss of cortical cells and decreased lymphopoiesis.
An increased number of Hassall's corpuscles, a marker of thymic aging, was observed.
Proteomics analysis identified significant alterations in thymic protein expression post-DOX treatment.

Conclusions:

Doxorubicin (DOX) treatment leads to thymic senescence.
DOX negatively impacts T-cell maturation by affecting thymic structure and function.
These findings highlight a previously understudied toxic effect of DOX on the immune system.