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ACTH induced sodium appetite in the rat.
Pharmacology, Biochemistry, and Behavior
|April 1, 1978
Summary
Synthetic adrenocorticotropic hormone (ACTH) injections significantly increased salt and water intake in rats, highlighting a specific mineral appetite. This effect was dependent on adrenal hormones, as it was absent in adrenalectomized rats.
Area of Science:
- Endocrinology
- Neuroscience
- Physiology
Background:
- Adrenocorticotropic hormone (ACTH) plays a crucial role in regulating adrenal gland function.
- The adrenal hormones influence various physiological processes, including electrolyte and water balance.
- Understanding the specific appetite regulation mechanisms is vital for metabolic and endocrine research.
Purpose of the Study:
- To investigate the effect of synthetic ACTH on salt and water intake in rats.
- To determine the specificity of the mineral appetite induced by ACTH.
- To elucidate the role of adrenal hormones in mediating ACTH-induced appetite changes.
Main Methods:
- Rats received daily subcutaneous injections of long-acting synthetic ACTH (5 U/day).
- Mineral intake (NaCl, KCl, MgCl2, CaCl2) and water intake were monitored.
- Experiments were conducted in both intact and adrenalectomized rats.
Main Results:
- ACTH administration led to a significant increase in 0.5 M NaCl and water intake.
- Sodium turnover approximated total body sodium by day five of treatment.
- The appetite was specific to NaCl; KCl, MgCl2, and CaCl2 intakes remained unchanged.
- ACTH was ineffective in adrenalectomized rats.
Conclusions:
- Long-acting synthetic ACTH stimulates a specific appetite for NaCl and water in rats.
- The observed mineral appetite is dependent on the presence of adrenal hormones.
- These findings suggest a critical role for the adrenal axis in regulating salt appetite.