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Related Experiment Video

Updated: Jun 8, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Contactants in 'Kum-Kum' dermatitis.

J V Kumar¹, R Moideen, S B Murugesh

¹Department of Dermatology and Venereology, JJM Medical College, Davangere-577004, India.

Indian Journal of Dermatology, Venereology and Leprology

|October 16, 2010

Summary

Contact dermatitis on the forehead was linked to Kum-Kum use in twenty patients. Patch tests confirmed Kum-Kum and its constituents, including brilliant lake red R, as the cause, not standard allergens.

Area of Science:

Dermatology
Allergology
Chemical Analysis

Background:

Contact dermatitis is a common skin condition.
Kum-Kum, a cosmetic product, has been anecdotally linked to dermatitis.
Identifying specific allergens is crucial for effective management.

Purpose of the Study:

To investigate the causative agents of forehead contact dermatitis in patients using Kum-Kum.
To determine if standard European allergens are responsible for the observed dermatitis.
To identify specific chemical constituents within Kum-Kum that elicit allergic reactions.

Main Methods:

Twenty patients with forehead contact dermatitis from Kum-Kum use were enrolled.
Patch testing was performed using commercial Kum-Kum, the extended European standard series, and specific identified constituents (brilliant lake red R, sudan I, aminoazobenzene, canaga oil).

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Last Updated: Jun 8, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Thin-layer chromatography was used to analyze the chemical composition of Kum-Kum.

Main Results:

All twenty patients showed positive patch test reactions to commercial Kum-Kum.
Positive reactions were also observed for brilliant lake red R, sudan I, aminoazobenzene, and canaga oil.
No positive reactions were noted with the extended European standard series of allergens.

Conclusions:

Commercial Kum-Kum is a significant cause of forehead contact dermatitis.
Specific constituents within Kum-Kum, namely brilliant lake red R, sudan I, aminoazobenzene, and canaga oil, are responsible for the allergic reactions.
Standard European allergen series are not implicated in this specific cohort's contact dermatitis.