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Related Concept Videos

Pedigree Analysis01:35

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Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
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Monilethrix in pedigree.

M P Shah1, R C Raval, F E Bilimoria

  • 1Department of Dermatology Civil Hospital, Ahmedabad, India.

Indian Journal of Dermatology, Venereology and Leprology
|October 16, 2010
PubMed
Summary
This summary is machine-generated.

This study identifies a rare genetic hair disorder causing beaded hair shafts in a patient and her family. The condition, characterized by moniliform appearance, co-occurred with psoriasis.

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Area of Science:

  • Dermatology
  • Genetics
  • Trichology

Background:

  • Psoriasis is a common chronic inflammatory skin condition.
  • Hair shaft abnormalities can be congenital or acquired, impacting hair structure and appearance.
  • Family history is crucial in diagnosing genetic dermatological conditions.

Purpose of the Study:

  • To report a case of a patient with beaded hair shafts and co-existing psoriasis.
  • To investigate the familial occurrence of the hair abnormality.
  • To highlight the diagnostic features of monilethrix.

Main Methods:

  • Clinical examination of scalp lesions and hair.
  • Microscopic examination of hair shafts for structural abnormalities.
  • Review of patient's and family members' medical history.

Main Results:

  • The patient presented with papular scalp lesions and sparse, short, curly hair (8-12 mm).
  • Microscopic analysis confirmed a beaded, moniliform appearance of the hair shafts.
  • The patient's father, two sisters, and daughter exhibited similar beaded hair characteristics.
  • The patient also had concurrent psoriasis lesions for two months.

Conclusions:

  • The case illustrates a likely inherited hair shaft disorder presenting with monilethrix.
  • The co-occurrence of psoriasis suggests potential links or independent conditions.
  • Familial aggregation supports a genetic basis for the beaded hair anomaly.