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Urinary Bladder

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Related Experiment Video

Updated: Jun 8, 2026

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

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Published on: August 18, 2014

TRPV4 as a target for bladder overactivity.

Patrizia Angelico¹, Rodolfo Testa

¹Pharmaceutical R&D Division, RECORDATI S.p.A. Via Civitali 1, 20148 Milano Italy.

F1000 Biology Reports

|October 16, 2010

Summary

This summary is machine-generated.

Transient receptor potential vanilloid 4 (TRPV4) channels in the bladder may be key mechanosensors. Inhibiting these channels could offer new therapies for overactive bladder and storage issues.

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Last Updated: Jun 8, 2026

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Published on: November 28, 2019

Area of Science:

Urology
Physiology
Pharmacology

Background:

Transient receptor potential vanilloid 4 (TRPV4) channels are implicated as mechanosensors in the urinary bladder.
Recent studies suggest TRPV4 channel modulation could treat overactive bladder and storage dysfunction.

Purpose of the Study:

To review the emerging role of TRPV4 channels in bladder function.
To highlight the potential of TRPV4 antagonists as a novel therapeutic strategy for bladder overactivity.

Main Methods:

Literature review of recent publications (last 2-3 years) on TRPV4 channels in the urinary bladder.
Analysis of studies focusing on TRPV4 agonists and the emergence of TRPV4 antagonists.

Main Results:

TRPV4 channels are strong candidates for mechanosensing in the human and animal urinary bladders.
Current research has primarily focused on TRPV4 agonists, with antagonists reported only recently.

Conclusions:

TRPV4 channel inhibition shows promise as a novel therapeutic approach for overactive bladder.
Further evaluation of TRPV4 antagonists in various models of bladder overactivity is warranted.