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Updated: Jun 8, 2026

Synthesis of Cationized Magnetoferritin for Ultra-fast Magnetization of Cells

Synthesis of Cationized Magnetoferritin for Ultra-fast Magnetization of Cells

Published on: December 13, 2016

Self-assembled magnetic filter for highly efficient immunomagnetic separation.

David Issadore¹, Huilin Shao, Jaehoon Chung

¹Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA.

|October 16, 2010

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A novel self-assembled magnetic filter efficiently separates magnetically tagged cells using a simple microfluidic chip. This inexpensive device achieves high enrichment factors and demonstrates utility in sorting tumor cells from leukocytes.

Area of Science:

Biotechnology
Microfluidics
Materials Science

Background:

Efficient cell separation is crucial for diagnostics and research.
Existing microfluidic separation methods can be complex and expensive.

Purpose of the Study:

To develop a compact, inexpensive, and efficient microfluidic device for removing magnetically tagged cells.
To characterize the performance of the self-assembled magnetic filter for cell separation.

Main Methods:

Fabrication of a microfluidic chip with a self-assembled Neodymium-Iron-Boron (NdFeB) magnet.
Utilizing the strong magnetic field gradient generated by the self-assembled magnet for magnetic separation.
Characterization using polystyrene and iron oxide beads, and application in sorting tumor cells from leukocytes.

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Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

Published on: June 23, 2022

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

Published on: February 16, 2017

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Last Updated: Jun 8, 2026

Synthesis of Cationized Magnetoferritin for Ultra-fast Magnetization of Cells

Synthesis of Cationized Magnetoferritin for Ultra-fast Magnetization of Cells

Published on: December 13, 2016

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

Published on: June 23, 2022

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function

Published on: February 16, 2017

Main Results:

The self-assembled magnetic filter generates a strong magnetic field gradient comparable to state-of-the-art microfabricated magnets.
Achieved enrichment of non-magnetic beads over magnetic beads by a factor of >10^5 with 90% recovery at 1 mL/h.
Successfully sorted tumor cells from leukocytes using negative immunomagnetic selection.

Conclusions:

The self-assembled magnetic filter offers a simple, cost-effective, and highly efficient solution for magnetic cell separation.
The device shows significant potential for applications in cancer diagnostics and cell-based research.
This technology enables compact and integrated microfluidic systems for cell analysis and isolation.