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Identification of Quiescent Cells in a Zebrafish T-Cell Acute Lymphoblastic Leukemia Model Using Cell Proliferation Staining
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T-lineage lymphoblastic lymphoma and leukemia-a MASSive problem
1Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. charles.mullighan@stjude.org
Abstract:
T cell precursor malignancies may present as T-lymphoblastic lymphoma (T-LBL) with marked enlargement of lymph nodes or acute T-lymphoblastic leukemia (T-ALL) with little lymph node enlargement. In this issue of Cancer Cell, Feng et al. show that dysregulation of BCL2, AKT signaling, and cell adhesion pathways are hallmarks of T-LBL.
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