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Updated: Feb 8, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Osteosarcoma after radiotherapy for prostate cancer.

John A Papalas¹, John D Wylie, Robin T Vollmer

¹Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. Papal002@mc.duke.edu

Annals of Diagnostic Pathology

|October 19, 2010

Summary

Postradiation osteosarcoma is a rare complication after prostate cancer radiation therapy. Clinicians should consider this rare bone cancer in patients with pelvic lesions mimicking disease relapse.

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Last Updated: Feb 8, 2026

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Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

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Published on: March 14, 2014

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

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Area of Science:

Oncology
Radiotherapy
Bone Sarcomas

Background:

Postradiation sarcomas are recognized long-term complications of cancer radiotherapy.
High-dose radiotherapy is a standard treatment for localized prostate adenocarcinoma.
Osteosarcoma is a rare but serious potential complication.

Observation:

This report details a case of osteosarcoma of the pubic ramus.
The patient had a history of prostate cancer treated with radiation therapy 10 years prior.
The presentation mimicked recurrent or metastatic prostate cancer due to lytic bone lesions and soft tissue involvement.

Findings:

Radiation-induced osteosarcoma in prostate cancer patients is rare.
The latency period can be long, leading to diagnostic challenges.
Prognosis is poor, with a 50% mortality rate within the first year.

Implications:

Clinicians must consider radiation-induced osteosarcoma in patients with a history of prostate cancer and new pelvic bone lesions.
Early diagnosis and appropriate management are crucial for improving patient outcomes.
This case highlights the importance of long-term surveillance for potential complications after radiotherapy.